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KMID : 0903520040470020251
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2004 Volume.47 No. 2 p.251 ~ p.257
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Screening of Biologically Active Compound from Edible Plant Sources-IX. Isolation and Identification of Sesquiterpene Lactons Isolated from the Root of Ixeris dentata forma albiflora; Inhibition Effects on ACAT, DGAT and FPTase Activity
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Bang Myun-Ho
Jang Tae-O
Song Myoung-Chong
Kim Dong-Hyun
Kwon Byoung-Mog
Kim Young-Kook
Lee Hyun-Sun
Chung In-Sik
Kim Dae-Keun
Kim Sung-Hoon
Park Mi-Hyun
Baek Nam-In
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Abstract
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The root of Ixeris dentata forma albiflora was extracted with 80% aqueous MeOH and solvent fractionated with EtOAc, n-BuOH and water, successively. From the EtOAc and n-BuOH fractions, four sesquiterpene compounds were isolated through the repeated silica gel and ODS column chromatographies. The chemical structures were determined as zaluzanin C (1), 9α-hydroxyguaian-4(15),10(14),11(13)-triene- 6,12-olide (2), 3β-O-β-D-glucopyranosyl-8α-hydroxyguaian-4(15),10(14)-diene-6,12-olide (3), and 3β-O-β-D-glucopyranosyl-8β- hydroxyguaian-10(14)-ene-6,12-olide (4) through the interpretation of several spectral data including 2D-NMR. Some showed the inhibitory effects on DGAT (Diacylglycerol acyltransferase), (IC50 values of 1, 2: 0.13, 0.10 mM), the catalyzing enzymes of the intracellular esterification of diacylglycerol and FPTase (Farnesyl-protein transferase), (IC50 values of 1, 2: 0.15, 0.18 mM), the farnesylation enzyme for Ras protein charge of cancer promotion.
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KEYWORD
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Ixeris dentata forma albiflora, guaianolide, ACAT, DGAT, FPTase
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